What Is PGT? Chromosomal and Genetic-Disease Screening Explained

A clear explainer of what PGT actually screens for — and what it doesn't.

⚕ Scope: Chromosomal and genetic-disease screening only
Bottom line up front: PGT screens embryos for chromosomal abnormalities (PGT-A) or specific known genetic diseases (PGT-M/PGT-SR) before transfer — a medical screening tool, not a general trait-selection technology.

PGT-A: Chromosomal screening

Screens embryos for the correct number of chromosomes (aneuploidy), which relates closely to implantation success and miscarriage risk, particularly relevant for patients of advanced maternal age.

PGT-M: Monogenic (single-gene) disease screening

Screens embryos for a specific, known genetic disease that runs in a family — used by carriers of conditions like cystic fibrosis, sickle cell disease, or Huntington's disease who want to avoid passing on that specific condition.

PGT-SR: Structural rearrangement screening

Screens for chromosomal structural rearrangements, relevant for carriers of balanced translocations who face elevated miscarriage risk.

PGT content on this site is scoped strictly to chromosomal screening (PGT-A) and known genetic disease screening (PGT-M/PGT-SR) — not sex selection or non-medical trait selection.

What PGT requires practically

A small number of cells are biopsied from the developing embryo (typically at the blastocyst stage) and analyzed, with results typically available before deciding which embryo to transfer.

See colombianivf.com for PGT-specific provider information at Colombia-based fertility clinics.

The Takeaway

PGT is a screening tool for specific, defined medical purposes — chromosomal health and known genetic disease risk — understand which specific type applies to your situation before pursuing it.